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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cholesterol-dependent cytolysin ： ウィキペディア英語版 Cholesterol-dependent cytolysin Cholesterol-dependent cytolysins (CDC) are a family of β-barrel pore-forming exotoxins that are secreted by Gram-positive bacteria. CDC are secreted as water-soluble monomers of 50-70 kDa, that once bound to the target cell, will form a circular homo-oligomeric complex containing up to 40 monomers,〔 although it is possible that some may incorporate more monomers. Through multiple conformational changes, the β-barrel transmembrane structure (~250Ǻ in diameter depending on the toxin) is formed and inserted into the target cell membrane. The presence of cholesterol in the target membrane is required for pore formation, though presence of cholesterol is not required by all CDC for binding. Intermedilysin (ILY) secreted by ''Streptococcus intermedius'' will bind only to target membranes containing a specific protein receptor, but cholesterol is required by intermedilysin (ILY) for pore formation. The lipid environment of cholesterol in the membrane can affect toxin binding, though the exact molecular mechanism that cholesterol regulates the cytolytic activity of the CDC is not totally understood. ==Cyto-lethal effects== Once the pore is formed within the target cell membrane, the regulation of the intracellular environment and what enters and leaves the cell is lost. The pore being ~250Ǻ in diameter is large enough to allow the loss of amino acids, nucleotides, small and large proteins as well as ions (Ca2+,Na+, K+, etc.). The loss of calcium in particular, which is involved in multiple molecular pathways will have a large impact on cell survival. The pore will also lead to an influx of water, which may lead to blebbing and cell death. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cholesterol-dependent cytolysin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.